Alzheimer's disease

Knowledge Identifier: $Alzheimer's_disease

add

Alzheimer's disease

Most common form of dementiaadd

Category: Sciences (200)

Launched in 1977.

Countries: Canada (40%), (20%), (20%)

Main connections: Alice Munro, Away from Her, Curcumin

Linked to: Alzheimer's Association, Alzheimer's Disease and Related Disorders Association, American Psychiatric Association, National Institute for Health and Clinical Excellence

 

Timeline


 

This timeline needs to be reviewed and corrected, as it has been automatically generated from multiple web sources.
Please help improve it by adding dated informations, images and videos about Alzheimer's disease.


1977

The terminology changed after 1977 when a conference on AD concluded that the clinical and pathological manifestations of presenile and senile dementia were almost identical, although the authors added that this did not rule out the possibility that they had different causes add something


1984

The National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association established the most commonly used NINCDS-ADRDA Alzheimer's Criteria for diagnosis in 1984, extensively updated in 2007 add something


2004

"The Notebook" , based on Nicholas Sparks' 1996 novel of the same name; "A Moment to Remember" ;"Thanmathra" ; "Memories of Tomorrow " , based on Hiroshi Ogiwara's novel of the same name; "Away from Her" , based on Alice Munro's short story "The Bear Came over the Mountain" add something


2006

In 2006, there were sufferers worldwide add something


2008

As of 2008 there is no concrete evidence that cannabinoids are effective in improving the symptoms of AD or dementia add something


2009

In 2009, this theory was updated, suggesting that a close relative of the beta-amyloid protein, and not necessarily the beta-amyloid itself, may be a major culprit in the disease add something


2010

Alzheimer's was diagnosed in one-third of the people who did not have any symptoms in a 2010 study, meaning that disease progression occurs well before symptoms occur add something

 

Curcumin as of 2010 has not shown benefit in people even though there is tentative evidence in animals add something


2015

Physical activity is associated with a reduced risk of AD. A 2015 review suggests that mindfulness-based interventions may prevent or delay the onset of mild cognitive impairment and Alzheimer's disease add something


2017

In early 2017, a trial of verubecestat, which inhibits the beta-secretase protein responsible for creating beta-amyloid protein was discontinued as an independent panel found "virtually no chance of finding a positive clinical effect" add something


2018

A 2018 review of the effectiveness of RT found that effects were inconsistent, small in size and of doubtful clinical significance, and varied by setting add something


2019

The association with celiac disease is unclear with a 2019 finding no increase in dementia overall in those those with CD while a 2018 review found an association with several types of dementia including AD. add something