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Because he was Jewish, he left Nazi Germany in 1933 and moved to Italy, however due to the anti-semitism of the Italian Fascist regime he moved to the Soviet Union in 1936
Kletzki's most notable work is his Third Symphony, completed in October 1939, with the subtitle 'In memoriam'
Other works include three string quartets, a Sinfonietta for strings, a Fantasy for piano, and a sonata for violin and piano. From 1942 onwards Kletzki wrote no more compositions; he argued that Nazism had destroyed his spirit and his will to compose
In 1954 he was appointed chief conductor of the Liverpool Philharmonic Orchestra